Chromosomal aberrations at very low radiation dose rates
نویسندگان
چکیده
منابع مشابه
Retrospective assessment of radiation dose by Fluorescence In Situ Hybridization and evaluation of stable chromosomal aberrations
Estimation of absorbed dose for radiation workers or person involved in different radiological accident is the aim of biodosimetry. Cytogenetic methods are the most current and applicable biodosimetry tools. In chronic or protracted exposure, fluorescence in situ hybridization (FISH), stable chromosomal aberration is used for estimation of absorbed dose. For precise estimation of absorbed dose,...
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Purpose: The relationship between biological effects and low doses of radiation is still uncertain, especially for high-LET radiation exposures. Estimates of risk from exposure to low doses and low dose rates are often extrapolated from the Japanese atomic bomb survivor data using either linear or linear-quadratic models fitted to dose–response data. In this study, we determined the dose–respon...
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introduction: ionizing radiation induces various kinds of dna damage in which may lead to chromosomal aberrations (ca). inspite of growing importance in the risk assessment, the dose yield kinetics of ca and their implications for dose assessment are not well established in exposures to low level radiation. in the present study, cytochalasin-b blocked micronucleus assay and metaphase analysis w...
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Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (microGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion which is a c...
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The frequency of translocations induced in diploid conidia of Aspergillus nidulans by gamma rays was much higher than that of recessive mutants involving a single chromosome. More than half of the surviving nuclei contained viable translocations at radiation doses within the range normally employed for induction of mutants in microorganisms.
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ژورنال
عنوان ژورنال: Nature
سال: 1979
ISSN: 0028-0836,1476-4687
DOI: 10.1038/277512a0